The A76 Dumfries to Kilmarnock road is closed at Thornhill after a serious road traffic accident.
Police say the road may be closed for a number of hours. Diversions are in place.
The clean-up of 18 tonnes of glue is well underway, after a lorry shed its load on the A76 at Sanquhar earlier today (22nd February).
Council workers have been using sand to try and soak up the substance.
The road is expected to be closed until at least 5pm this evening.
Council roads workers have been brought in to clean up the 15,000 litres of glue currently spread across the road.
Sans is being poured over the glue, in the hope of absorbing the sticky substance.
Police say the A76 outside of Sanquhar will remain closed for most of the day, after a glue lorry overturned.
Around 400 metres of the road is currently covered in glue.
The diversion currently in place is:
Southbound onto A70 at Cumnock, onto then B7078 to Abington Services, onto A702, then rejoin the A76.
Police advise northbound motorists to reverse this route.
Around 400 metres of road is covered in glue on the A76, near Sanquhar, after a lorry overturned.
The road is expected to be closed for several hours.
The current diversion is 50 miles long.
The A76 through Sanquhar is currently closed due a road crash which involved a lorry loaded with glue.
The glue container on the lorry has burst and glue spilling is affecting the road surface.
Diversions are being put in place but drivers are being asked to avoid the area.
Police are warning motorists that several roads in the region are suffering hazardous conditions.
There's heavy snow reported on A74 northbound at junction 15 and black ice on the A76 near Auldgirth.
Ice has also been reported on the A713 north of Carsphairn.