The A701 is closed in both directions north of Amisfield at Parkgate, due to an accident.
Traffic between Dumfries and Moffat is being affected.
One person has been taken to hospital after a four vehicle crash on he A595 at Moor Row Road Ends.
The road is closed at Clintz Brow roundabout and Mirehouse Road and diversions are in place.
To get to Workington, motorists are advised to come off at Clintz Brow and go via Cleator Moor.
To get to Egremont, turn off at Mirehouse.
All motorists are advised to avoid the areas.
The B724 road is blocked about two miles west of Annan, near to the Newbie junction, due to a crash.
Emergency services are at the scene and drivers are being asked to avoid the area.
One lane is closed on the M6 southbound between junction 37 (Kendal) and junction 36 (Kirby Lonsdale), due to an accident.
Matrix sign set to 50 mph.
Police are appealing for witnesses after ten people were injured in a multiple-car pile up in the Scottish Borders.
The accident happened at 5.10pm on the A68 near Soutra Hill last night (26th August).
A Honda Civic was travelling north when it was involved in a collision with several other vehicles travelling south.
Five people were taken to the Royal Infirmary of Edinburgh, including the driver and passenger from the Honda, who suffered serious injuries.
One lane of the A74(M) southbound is blocked due to an accident between junction 22 (Gretna Green) and junction 45 of the M6 (Gretna).
The air ambulance is on its way to an accident on the A595.
The road is closed in both directions between A66 (Bridgefoot Roundabout) and the A596 near Winscales.
Motorists should expect delays.
The slip-road at junction 36 (Kirkby Lonsdale) on the M6 northbound is blocked, due to an accident.
The A74 (M) Northbound is now clear after an earlier accident between junction 17 (Lockerbie) and junction 17 (Johnstonbridge), which resulted in a fuel spillage.
The A74 (M) Northbound is partially blocked due to an accident between junction 17 (Lockerbie North) and junction 16 (Johnstonbridge).