One lane of the A74(M) southbound is blocked due to an accident between junction 22 (Gretna Green) and junction 45 of the M6 (Gretna).
The air ambulance is on its way to an accident on the A595.
The road is closed in both directions between A66 (Bridgefoot Roundabout) and the A596 near Winscales.
Motorists should expect delays.
The slip-road at junction 36 (Kirkby Lonsdale) on the M6 northbound is blocked, due to an accident.
The A74 (M) Northbound is now clear after an earlier accident between junction 17 (Lockerbie) and junction 17 (Johnstonbridge), which resulted in a fuel spillage.
The A74 (M) Northbound is partially blocked due to an accident between junction 17 (Lockerbie North) and junction 16 (Johnstonbridge).
Three people have been injured as a result of a collision between a Ford Fusion and a Toyota Landcruiser at junction 39 (Shap), on the M6 at 2.40pm this afternoon.
A 78-year-old woman from Warrington, who was driving the Ford Fusion, was airlifted to the Royal Victoria Infirmary in Newcastle, alongside 78-year-old male passenger who was also injured.
A 78-year-old man from Carlisle, who was driving the Toyota Landcruiser, was taken to the Cumberland Infirmary in Carlisle with minor injuries.
The road has been closed for almost three hours but is set to re-open shortly.
The entry and exit slip roads at junction 39 (Shap) on the M6 in Cumbria are closed, due to a two-vehicle accident.
The A66 is closed in both directions between the A5086 (Cockermouth roundabout) and A591/A5271 (Crosthwaite Road), due to a serous accident.
Two vehicles are involved and the air ambulance is at the scene.
A man from Wigton is in a serious condition after a two vehicle collision on the A6 between Penrith and the Stoneybeck roundabout.
The 55-year-old was driving a Citroen Berlingo when the accident happened at around 2.20pm.
He was airlifted to the Royal Victoria Infirmary in Newcastle.
A 42-year-old woman from Carlisle, who was driving the Kia Sedona involved in the accident, has been taken to Cumberland Infirmary in Carlisle, along with her 49-year-old male passenger.
The A6 remains closed from the Stoneybeck roundabout.
Police say a twenty month old girl who was trapped under a car at a Lake District camp site owes her life to the quick thinking of other campers.
The child is in a serious condition in hospital after suffering head, leg and pelvic injuries following the incident at Lanefoot Farm, near Keswick.
Kenny Toal reports: