The A74 (M) Northbound is partially blocked due to an accident between junction 17 (Lockerbie North) and junction 16 (Johnstonbridge).
Three people have been injured as a result of a collision between a Ford Fusion and a Toyota Landcruiser at junction 39 (Shap), on the M6 at 2.40pm this afternoon.
A 78-year-old woman from Warrington, who was driving the Ford Fusion, was airlifted to the Royal Victoria Infirmary in Newcastle, alongside 78-year-old male passenger who was also injured.
A 78-year-old man from Carlisle, who was driving the Toyota Landcruiser, was taken to the Cumberland Infirmary in Carlisle with minor injuries.
The road has been closed for almost three hours but is set to re-open shortly.
The entry and exit slip roads at junction 39 (Shap) on the M6 in Cumbria are closed, due to a two-vehicle accident.
The A66 is closed in both directions between the A5086 (Cockermouth roundabout) and A591/A5271 (Crosthwaite Road), due to a serous accident.
Two vehicles are involved and the air ambulance is at the scene.
A man from Wigton is in a serious condition after a two vehicle collision on the A6 between Penrith and the Stoneybeck roundabout.
The 55-year-old was driving a Citroen Berlingo when the accident happened at around 2.20pm.
He was airlifted to the Royal Victoria Infirmary in Newcastle.
A 42-year-old woman from Carlisle, who was driving the Kia Sedona involved in the accident, has been taken to Cumberland Infirmary in Carlisle, along with her 49-year-old male passenger.
The A6 remains closed from the Stoneybeck roundabout.
Police say a twenty month old girl who was trapped under a car at a Lake District camp site owes her life to the quick thinking of other campers.
The child is in a serious condition in hospital after suffering head, leg and pelvic injuries following the incident at Lanefoot Farm, near Keswick.
Kenny Toal reports:
A toddler is in a serious condition in hospital after an accident at a campsite in the Lake District.
The girl, who is 20 months old, is being treated in Newcastle's RVI hospital after she became trapped under a van at Lanefoot Campsite at Thornthwaite, near Keswick on Sunday morning.
She is reported to have serious head, leg and pelvis injuries but her condition is not thought to be life threatening.
The A66 in at Penrith has partially reopened following an earlier accident involving three cars and a lorry between Kemplay Bank roundabout and Temple Sowerby.
The A66 Penrith is closed in both directions due to an accident involving three cars and a lorry between Kemplay Bank roundabout and Temple Sowerby.
The accident happened near to Center Parks and traffic between Penrith and Temple Sowerby is being affected.
All lanes have reopened on the M6 southbound in Cumbria between junctions 43 and 44, following an earlier accident.