The A689 at Wallfoot near Carlisle has re-opened following a crash involving three vehicles, including a mini-bus carrying seven children.
The children aged between 13 and 14, and two adults were taken to the Cumberland Infirmary as a precaution.
The driver of the mini-bus, aged 38 and from Northumberland, was airlifted to hospital.
His injuries are not believed to be serious.
A 51-year-old HGV driver from Essex and a local motorist escaped injury.
Police are appealing for witnesses to the crash, which closed the Carlisle to Brampton road for several hours.
Seven children have been taken to hospital after a mini-bus crash near Carlisle.
The mini-bus was in collision with a car on the A689 between Carlisle and Brampton at Walby.
The road remains closed in both directions.
The driver of the mini-bus has been airlifted to hospital.
It is not thought any of the children are seriously hurt.
A statement has been released from Dumfries bus company MacEwans Coach Services, after one of its buses carrying 13 passengers crashed outside Biggar around 8.30pm on 14th November.
Seven people were taken to hospital for treatment.
South Lanarkshire Council have confirmed that they are not responsible for this route and therefore are not involved in any discussions to improve safety on the route.
Eight people have been taken to hospital after a bus crash in South Lanarkshire.
The Edinburgh to Dumfries bus was involved in a collision near Biggar at 8:25pm on Wednesday evening.
There were 13 people on board including the driver. The 7 people were taken to 3 different hospitals.
Strathclyde Police say none of the injuries are life-threatening.