Up to 17 people are believed to have been injured in a two-vehicle collision involving a coach.
Emergency services were called to the scene on the A685 at Tebay shortly after 5pm today and are currently dealing with the incident.
Police say none of those hurt have suffered life-threatening injuries.
The road is closed and is expected to remain shut for some time. Motorists are asked to avoid the area and use alternative routes.
An 86-year-old man has been seriously injured after being struck by a car.
He was taken to the Cumberland Infirmary in Carlisle.
A 27-year-old Maryport woman, who was driving the Volkswagen Polo, suffered no injuries.
The Dalston Road between Richardson Street and Long Sowerby Road, has now reopened.
Two people are in hospital with serious injuries after a crash between two cars near Carlisle.
It happened at half past 7 last night (Nov 20th) just east of the Thursby roundabout on the A596.
The police say a silver Vauxhall Vectra, driven by a 22-year-old man from Maryport, and a silver Ford Mondeo, driven by a 67-year-old woman from Carlisle, were travelling in opposite directions when they collided.
Both were taken to hospital in Carlisle where they remain in a serious but stable condition.
The road was closed for four and a half hours.
The A5086 has been closed following a serious crash.
Police were called at 4:27pm after two vehicles road collided on at A5086 near Oakhurst roundabout.
The Fire Service and Ambulance service are at the scene.
All motorists are asked to avoid the area and use alternative routes. Those in traffic are asked to remain patient.
A man has been airlifted to hospital following a crash on the A66 near Brough, Kirby Stephen.
The man, who was driving the van, is believed to have potentially serious injuries.
Police are asking drivers to find alternatives routes as the road remains closed. Traffic is being re-directed at Coupland Beck and Penrith.
The collision happened today, Wednesday 21 May, at 8:20am.
Police are asking drivers to avoid the A66 at Brough, Kirby Stephen, where a serious crash is being dealt with by emergency services.
The collision, involving a van and a lorry, happened at 8:20am this morning, Wednesday 21 May.
The extent of the drivers injuries is unknown at this time.
For traffic updates visit www.cumbria.police.uk/traffic.
Diversions are in place after a crash on the A66.
The A66 is closed in both directions from the Sheep and Wool Centre to Crosthwaite Roundabout.
Diversions are in place along the A595 to Bothel and A591 to Keswick.
The police in Cumbria are currently dealing with a serious road accident on the A66. It happened at the junction between Lorton and Buttermere. The road is closed and diversions are being put in place.
A motorcyclist who died in a crash with a lorry in West Cumbria has been named. He was 47-year-old Dean Sheffield, from Frizington. The accident happened on the A595 near the Sellafield site on Thursday morning
The motorcyclist who was involved in a collision at Carronbridge on the A76 on Saturday (13th July) has died.
41-year-old Michael Blair, from Ballochmyle Avenue in Auchinleck, was taken to the Southern General Hospital for treatment in Glasgow, but died from his injuries.
The Procurator Fiscal has been informed.