The A6 at Shap summit was closed both ways due to a two-vehicle crash between Forest Hall and J39 of the M6.
All lanes have now been re-opened.
There are currently no reports as to whether anyone has been injured.
Police advised motorists to be patient while they arranged vehicle recovery to clear the road.
A man has been taken to Carlisle's Cumberland Infirmary, with what are believed to be non-life threatening injuries, after a six-vehicle crash near the city.
It happened at around 10.30am on the A7 at Westlinton, involving several cars and one van.
Another man was also injured and treated by paramedics at the scene.
All lanes have been re-opened.
A man who died after being involved in a collision on the A66 has been named by police as 92-year-old Alec Bond, of Cockermouth.
Mr Bond died on Friday 22 December at the Royal Victoria Infirmary in Newcastle, following the crash on Tuesday 19 December, where the he car driving collided with a lorry near to Threlkeld.
The death has been referred to the HM Coroner for Newcastle.
Anyone with information should call PC691 Ormerod on 101.
The collision took place at 1.45pm on Sunday 15 October at Sebergham near Wigton on the B5305.Read the full story ›
25-year-old Calum Wilkinson who caused the death of a pensioner has told a jury: "I will carry that with me for the rest of my life."Read the full story ›
82-year-old David Bennell is on trial, after being accused of causing a pensioner's death in a "horrific" head-on A66 smash.Read the full story ›
Police in the Scottish Borders are appealing for witnesses following a serious road collision on the A697.Read the full story ›
The A711 in Dumfries and Galloway has been closed due to an accident west of Cargenbridge.
Police Scotland are asking drivers to follow the temporary diversions in place.
A drink-driver who caused a head-on A66 crash which "ruined" a couple's lives has been jailed for three years.Read the full story ›
A four-year-old girl is in a serious condition in hospital after the car she was travelling in was involved in a crash on the A69.
The two-vehicle collision happened between Brampton and Corby Hill at 8.45am.
A 43-year-old woman from Carlisle, who was driving the Vauxhall Astra, was also taken to the Cumberland Infirmary with serious, but not life-threatening, injuries.
A 46-year-old male driver of a Land Rover, also involved in the crash, did not suffer any injuries.