Two riders being transported to hospital. It is not clear at this time the extent of their injuries.
The A686 is currently closed a Melmerby and Alston and motorists are advised to avoid the area and use alternative routes.
The crash is believed to have involved at least two motorbikes. the condition of the riders involved is not known at this time, although the Air Ambulance has been deployed. The road will be closed for some time.
Five people were injured last night (9th July) after two cars were involved in a head on collision on the A711 Dalbeattie to Dumfries road.
The cars crashed in the Long Wood areas, about three miles west of Dumfries.
One person was left with serious injuries and was air lifted to Dumfries and Galloway Royal Infirmary.
The other four people were treated at the scene before being taken to hospital, and the road remained closed for several hours.
Police Scotland are appealing for any witnesses with information to contact them on 101.
A woman has died following a crash on the A65.
The 3 vehicle collision happened at Spital, between the M6 and Kirby Lonsdale, on Saturday 20th April.
Another woman has been airlifted to hospital with serious injuries.
The family of a teenager who died in a crash in Penrith on Thursday (7th March) have paid tribute to a ‘much loved’ man who was a ‘devoted dad’.
19-year-old Robin Hewitt, from Milner Mount in Penrith, died in the accident near Eamont Bridge.
He was a passenger in a BMW car which hit a tree by the side of the B5320.
The 23-year-old driver has been arrested on suspicion of causing death by dangerous driving.
A spokesperson from Robin's family said:
"Robin was a much loved son and brother and was a devoted father to Leon.
“He will be very sadly missed by his parents Susan and Phillip, his brothers, Robert and Ross, and all the extended family members.”
The A6071 Carlisle Road in Brampton near Carlisle is closed in both directions due to a three vehicle crash.
The 23-year-old man who died in a crash near Lochamaben has been named as Michael Goldie from Lockerbie.
Mr Goldie was driving a white Honda CRX when the incident happened at around 10.15pm last night (30th January).
He died at the scene.
A 21-year-old male passenger was taken to Dumfries and Galloway Royal Infirmary after sustaining serious injuries.
A man has died in a crash on the A709 between Lochmaben and Lockerbie in Dumfries and Galloway.
The 23-year-old was driving a white Honda CRX when the incident happened at around 10.15pm last night (30th January).
The driver died at the scene and a 21-year-old male passenger was taken to Dumfries and Galloway Royal Infirmary after sustaining serious injuries.
His condition is described as serious but stable.
Both men are thought to be local.
Anyone who witnessed the accident or seen the car before the accident is asked to contact police on 0845 600 5701.
A woman has died in a road accident on the A701 at Marchbank Woods near Beattock in Dumfries and Galloway.
The accident happened at around 10am this morning (10th January).
A man has been taken to Dumfries and Galloway Royal Infirmary for treatment.
The road is closed and diversions are being put in place.
The northbound stretch of the motorway between J37 and J38 was shut at around 9.40pm to allow vehicles to be recovered and for accident investigators to carry out investigations.
A spokesman for Cumbria Fire and Rescue Service said:
The road is now re-opened but police are urging motorists to take extra care while a weather warning remains in place until 11am Sunday due to predictions of wintry showers and ice.