All lines on the Virgin North Lakes train service as currently closed due to a fallen tree at Penrith.
Virgin Trains say delays of up to 20 minutes should be expected.
There are delays of up to one hour and thirty minutes on Virgin Trains between Glasgow Central and London Euston, and between Edinburgh Waverley and Birmingham New Street, due to a broken down freight train between Oxenholm Lake District and Lancaster.
This also affects First Transpennine Express trains.
There are currently delays of up to 40 minutes on Northern Rail trains travelling between Carlisle and Skipton, due to snow at Garsdale.
Delays of around 30 minutes can be expected on Northern Rail trains between Whitehaven and Sellafield, due to a landslip at Braystones.
There are temporary traffic lights on the A66 in both directions at Warcop in Cumbria, due to a broken down lorry.
The flat-bed lorry lost its trailer between Appleby and Brough, and delays can be expected whilst recovery takes place.
There's disruption on Virgin Trains between Lancaster and Carlisle due to flooding between Oxenholme Lake District and Penrith.
Delays of up to 60 minutes can be expected.
There are delays of up to 45 minutes on Virgin Trains between Carlisle and London Euston due to signalling problems at Alsager.