Hail, sleet and snow showers are expected to become frequent overnight and at first on Tuesday morning.
Heavier snowfall is likely to affect higher level routes where 2-5 cm of snow may accumulate in places, whilst 1 to 2 cm is possible to lower levels.
Some transport routes may be affected, with journeys requiring longer travel times.
Two people have died in a one-vehicle crash on the A711 near to Tower Wood in Dumfries.
The crash happened at around 9.52pm on Sunday 23 April.
The drive and passenger of a black Vauxhall Astra died at the scene.
The road re-opened around 4.47am hours this morning.
Constable Rebecca Wylie of the Road Policing Unit said:
We are carrying out a full crash investigation into this collision and would ask that anyone who may have witnessed it to get in touch with us at Dumfries on the 101 number. We are particularly keen to speak with the occupants of an estate car that we believed may have stopped at the scene shortly after the crash”.
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Cloud and patchy rain will quickly clear south during the morning introducing brighter but colder conditions.
During the afternoon there will be sunny spells and maybe a few wintry showers, especially over the hills.
Maximum temperature 11 °C.
Tourism bosses have come up with a new way to entice people into south-west Scotland - by getting them behind the wheel of their car.
Three driving routes have been created to take advantage of the area's outstanding scenery.
Our reporter, Matthew Taylor, went along for a ride:
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Police in Dumfries and Galloway are urging people to be vigilant, after reports of a man trying to use counterfeit £20 notes.
The reports have come from the Newton Stewart and Machars area, and police are asking shop keepers and market stall traders to report any suspicious activity to them.
Anyone with information should contact Police Scotland on 101.