Patients at Dumfries and Galloway Royal Infirmary put up with gruelling dialysis, waiting for a transplant that could change their lives.
The grandmother of a baby whose mother died just a few hours after giving birth is urging people to join the donor register.
When a Cumbrian teenager tragically died of meningitis her family made the decision to donate her organs, she saved three other lives.
The latest statistics show that there are more than 100 people in the Border region waiting for organ donations.
59 of them were in Cumbria, 14 on the waiting list in the Borders and another 28 in Dumfries and Galloway.
At present, both England and Scotland have an opt-in system where people voluntarily sign on to a register.
Campaigners are calling for the law to be changed so that everyone is automatically signed up to be a donor with the option to opt out.
Katie Hunter has been to meet two families on either side of the border with very different stories:
Students at Borders College are holding an Organ Donation Awareness Day.
They are have put together a promotional film to encourage other young people to think about organ donation.
The students campaign comes on the same day the Scottish Parliament is debating an opt out system for organ donation.
More than 4,000 transplants were carried out in the UK last year.
Figures from the Organ Donor website Since 1 April 2014:
- 113 people have donated organs
- 187 people have donated corneas
- 223 people have received the gift of sight
- 292 people have received transplants
- 6,963 people are still waiting for transplants
Students hope their campaign get people talking and get more people to join the Organ Donor Register.
Around eighty people are currently waiting for an organ transplant in the Borders.
In the last nine months of 2013, just a quarter of that number got lucky when organs became available.
Now a young man from Galashiels wants to turn organ donation into less of a lottery, by persuading more young people to register because he knows the difference it can make.
He's enlisted the help of Fixers - the campaign that gives young people a voice - to get across his difficult message.
He tells his story below. For more information on ITV Fixers click here.
A mother from Penrith who allowed her daughter's organs to be donated for transplant - after she died of a brain tumour - says it's been a great comfort to know that other lives have been saved.
Lesley Kremer is calling for organ donation to be made automatic, after her daughter Rosie died last year.
Her organs were given to five different patients.
Katie Oakes reports:
A mother who allowed her daughter's organs to be donated after she died of a brain tumour is backing the 'opt out' system.
The scheme, already in place in Wales, would mean that in the event of death, a person's organs could be used without giving consent.
It applies to over-18s who die in Wales if they have lived in Wales for more than 12 months.
Lesley Kremer's daughter died last year.
She spoke with Aled Jone and Lorraine Kelly on Daybreak:
A mum whose daughter's organs saved eight other lives hopes more people will sign up to be donors in her memory.
Lesley Kremer, from Penrith, has been been awarded the Order of St John in honour of Rosie - who died at the age of 24.
Katie Hunter reports.
If you, or someone that you know, would like to find out more about organ donation and about how you can get involved, click here.
A mum from Penrith hopes more people will sign up to the organ donation register in memory of her daughter.
Lesley Kremer has just been awarded the Order of St John in memory of Rosie, who died from a brain tumour hours after giving birth when she was 24.
The award is to recognise people posthumously whose deaths have saved lives.
Lesley told ITV Border she was "very proud" to receive the award on behalf of her daughter.
On average three people in the UK die every day waiting for suitable organs. Around 10,000 people currently need a transplant but only one in three of us is a registered donor.
Lesley's hopeful that Rosie's story will inspire more people to officially sign up.
Many leading doctors have said that an opt-out system for organ donation would better reflect the views of most Scots.
Practitioners from the British Medical Association (BMA), said that it was time for a 'serious debate' on organ donation.
– Doctor Sue Robertson, Renal physician
"All the time we waste now means that more lives will be lost. Now is the time for a serious debate about moving to opt-out."
ITV have been running the 'From the Heart' campaign, which has been encouraging people to consider joining the organ donor register.
Shelley Wealleans from Carlisle was asked whether she would donate her baby son's organs when he died at 11 weeks old. She said no, but has regretted it ever since.
Shelley now campaigns to encourage others to become organ donors. If you want to join the organ donor register, find more information at ITV's From the Heart website here.