A man has been taken to hospital by air ambulance, after a collision involving two cars on the A592 at Windermere.
The collision took place at 13:50, and a Honda Jazz and BMW 320 were involved.
The motorcyclist has been taken to Preston Hospital.
Motorists are advised to avoid the area, as the road will remain closed at Newby Bridge for at least another hour.
Police in Cumbria are concerned that 21 accidents took place on the county's roads in one day, at the weekend.
Nine of the collisions involved motorbikes, leaving some riders with serious injuries.
Police are calling for drivers to reduce their speed and leave sufficient braking distance from the driver in front.
The spate of accidents happened on Sunday.
Police are continuing to appeal for information after a three vehicle crash near Carlisle that left one man with 'life changing' injuries.
The crash happened at 11am on Sunday 22 June on the A6071 at the Roadhead junction near to Kirklinton, and involved two motorbikes and a Range Rover.
The driver of a Yamaha motorbike, a man from Sunderland, was taken to the RVI in Newcastle, where he remains with serious, non-life threatening injuries.
The driver of the Range Rover has contacted police officers.
Cumbria Police are appealing for anyone who was in the area at the time of the collision to contact them on the 101 non-emergency number.
Police have described the injuries suffered by the biker airlifted to the RVI as 'life changing' rather than life threatening.
The road is now reopened to traffic.
Two motorbikes and a car were involved in a serious crash at around 11am this morning.
Two bikes, a Yamaha and a BMW, were involved in an accident with a red Range Rover Evoque.
The BMW rider was seriously hurt. The rider of the other bike was uninjured.
Police are looking for the driver of the Range Rover which did not stop at the scene.
A 79-year-old woman has been seriously injured after a crash on the A66.
The three vehicle incident happened at 12:05pm yesterday, 24 May.
The woman, who is from Appleby, was airlifted to the Royal Victoria Infirmary in Newcastle.
No one else is thought to have been injured.
Crash debris has been cleared and the road is running normally.
The accident involved two cars and an HGV near the B6262 junction. Local diversions are in place and the police hope to have the route opened shortly. Police say they are not treating the accident as serious at this time.
The accident happened on the A590 between Melton and Lindal in Cumbria at 10.30 on Friday night. Twenty-three-year-old Scott Daniel Gibson from Barrow in Furness died at the scene.
The police officer who was driving the van was taken to Furness General Hospital suffering from shock.
The A711 is closed in both directions due to a serious accident involving two cars between the B793 (Dalbeattie) and Waterside Road in Dumfries.
Motorists should expect long delays.