The A590 is closed in both directions following a serious road traffic collision at Lindal in Ulverston.
The accident happened at around 5am and involved a Vauxhall Corsa and an HGV.
The 19-year-old driver of the Vauxhall Corsa, who is a man from Barrow, was airlifted to Royal Preston Hospital after suffering life threatening injuries.
The 39-year-old driver of the HGV, from Waberthwaite, suffered no injuries.
The fire service, air ambulance, and highway agency attended the scene.
The road is closed in both directions and will remain closed for the next three to four hours.
Police are asking motorists to avoid the driver and said light traffic can use the A5087 between Barrow and Ulverston.
HGV's are being asked to park up and wait or use A595 and A5092.
The A66 near Warcop is blocked in both directions following a three vehicle road traffic collision.
Cumbria Police were called at 12.29pm regarding the incident.
Drivers are advised to avoid the area and look for alternative routes.
Two of west Cumbria's main roads were shut by two serious accidents today, one of which saw a motorist die at the scene.
A 40-year-old Haltwhistle man died on the A595 after a collision between a car and a lorry.
In the second accident, a van driver was airlifted to hospital after a crash on the A66.
Kim Inglis has this report:
Cumbria Police say a two-year-old boy has suffered serious injuries in a road traffic collision near Kendal.
The collision happened at around 3.40pm on Sunday (26th May), outside the Eagle and Child pub in Staveley.
The boy was airlifted to the Royal Victoria Infirmary in Newcastle, where he is now in a stable condition.
A grey landrover freelander was involved in the incident and police are appealing for witnesses to come forward.
A 13-year-old girl is in a critical condition in hospital after being hit by a car in Workington.
The accident happened on Solway road at around 4pm on Saturday 25th May.
She was airlifted the the Royal Victoria Infirmary in Newcastle with serious head injuries.
The road was closed for 3 and a half hour as police examined the scene.
The vehicle involved was a silver Nissan Qachqai, being driven by a 59-year-old woman.
Cumbria Police are appealing for witnesses to the accident, and ask anyone that saw the car in the area at that time to get in touch.
Firefighters have cut a motorist free from a car following an accident near Castle Douglas.
The incident happened on the B795 at Gerranton Farm at lunchtime yesterday.
One person was taken to hospital by ambulance.
The motorway slip road at junction 42 on the M6 in Cumbria is closed in both directions, due to an overturned lorry.
Motorists are advised to use junctions 43 and 41 instead.
The road is expected to remain closed for several hours.
A 23 year old man has been arrested on suspicion of causing death by dangerous driving after a crash near Penrith last night.
It happened on the B5320 just outside Eamont Bridge when a BMW car hit a tree.
One of the passengers in the car, a man in his late teens from Penrith, died at the scene. The police want to hear from any witnesses or anyone who saw the car just before the accident.
A man has died in a road crash in Whitehaven.
The collision, involving one car, happened at around 2.30pm close to the Howgate Hotel.
Cumbria Police say the man, who is believed to be local and in his seventies, collided with a wall and was pronounced dead at West Cumberland Hospital.
Police are appealing for witnesses to contact PC Mark Ormerod in Cumbria Constabulary’s Roads Policing Unit on 101.
Police want to speak to the driver of a blue BMW, believed to have been involved in a serious accident on the A66 this morning (14th February).
The collision, involving a white Peugeot panel van and a white Vauxhall Vivaro van, happened at 10.30am.
The vans were travelling in opposite directions around two miles east of the Sportsman on the A66.
The 53-year-old driver of the Vivaro van, from Carlisle, was taken to the Cumberland Infirmary, with 'non-life threatening' injuries.
A 23-year-old passenger in the same van was airlifted to James Cook hospital in Middlesbrough with 'very serious' injuries.
The 33-year-old driver of the Peugeot van suffered back and rib injuries.
Anyone who knows the driver of the BMW or who witnessed the accident is asked to contact police on 101.