The A7 is closed in both directions due to a serious accident north of Longtown.
Traffic between Longtown and Canonbie is being affected.
The air ambulance is on its way to an accident on the A595.
The road is closed in both directions between A66 (Bridgefoot Roundabout) and the A596 near Winscales.
Motorists should expect delays.
The A66 is closed in both directions between the A5086 (Cockermouth roundabout) and A591/A5271 (Crosthwaite Road), due to a serous accident.
Two vehicles are involved and the air ambulance is at the scene.
The A66 Penrith is closed in both directions due to an accident involving three cars and a lorry between Kemplay Bank roundabout and Temple Sowerby.
The accident happened near to Center Parks and traffic between Penrith and Temple Sowerby is being affected.
The B5299 is closed in both directions due to a serious accident between B5305 (Welton) and The Green (Dalston).
The accident involved a car and a ‘mini’ digger.
The road is expected to remain closed for several hours and drivers are advised to avoid the area with diversions via the A595 and B5305.
Dumfriesshire, Clydesdale and Tweeddale MP David Mundell has called for urgent action after a section of road in Dumfries and Galloway collapsed into a stream.
The stretch of road on the A708 between Moffat and Selkirk, near to Grey Mare's Tail, is thought to have broken off after heavy rainfall.
Diversions are in place via Blyth Bridge, Peebles and Innerleithen, causing a long detour for motorists.
Mr Mundell has now written to the Scottish Transport Minister Keith Brown, urging him to provide support to Dumfries and Galloway Council.
"“Sadly this closure is something which has been going to happen for some time and I have repeatedly called for action to have this road upgraded.”
“The A708 is a direct link route between Dumfries and Galloway and the Scottish Borders and I and others have expressed concerns in the past about the condition along stretches of the scenic route.
"Sections of the road have collapsed before with barriers put in place, effectively creating single-file traffic.
“It is now clear that repairs and upgrades are beyond the resources of the local councils and that is why I have called on the Scottish government to get involved.
"This is an important A class road and one essential to tourism, transport and local people, therefore it is imperative it is fixed as soon as possible.
“Fortunately no one was injured in this incident but without investment there could be other similar incidents. It is not enough just to repair this section - there must be a longer term upgrade of this route,”
The M6 northbound has been closed between junctions 43 and 44 due to a multi-vehicle accident.
Police are at the scene.
The A596 in Cumbria is closed in both directions at Wigton, due to an accident involving a lorry and a car.
Wigton is very congested due to diverting traffic.
The motorway slip road at junction 42 on the M6 in Cumbria is closed in both directions, due to an overturned lorry.
Motorists are advised to use junctions 43 and 41 instead.
The road is expected to remain closed for several hours.
The B5289 at Honister Pass at Buttermere in Cumrbia is closed, due to snow.