The M6 northbound has been closed between junctions 43 and 44 due to a multi-vehicle accident.
Police are at the scene.
The A596 in Cumbria is closed in both directions at Wigton, due to an accident involving a lorry and a car.
Wigton is very congested due to diverting traffic.
The motorway slip road at junction 42 on the M6 in Cumbria is closed in both directions, due to an overturned lorry.
Motorists are advised to use junctions 43 and 41 instead.
The road is expected to remain closed for several hours.
The B5289 at Honister Pass at Buttermere in Cumrbia is closed, due to snow.
The A697 in the Scottish Borders is closed in both directions between A6105 Wester Row (Greenlaw) and A68 (Carfraemill), due to snow and an accident involving nine vehicles.
Vehicles are stuck in the snow, causing problems between Coldstream and Lauder.
The A68 in the Scottish Borders is closed in both directions due to an accident between A6088 (Carter Bar) and the A696/A68.
The A701 is closed in both directions at Amisfield in Dumfries and Galloway, due to an accident involving a lorry at Kirk Bank.
Traffic between Moffat and Dumfries is being affected, and a diversion is in place via Lochmaben.
The A77 is closed in both direction at Cairnryan in Dumfries and Galloway, due to flooding.
The A6 is closed in both directions near Wickersgill in Cumbria, due to a three vehicle accident at Hucks Brow.
The accident is affecting traffic between Shap and Kendal.
Police are advising motorists to travel via the M6.
The A592 Kirkstone Pass in Cumbria is now closed, due to snow and ice.