The B6413 will be closed between Lazonby and Kirkowald at Eden Bridge fro two weeks, starting form today (3rd June).
The road closure will allow for the installation of permanent traffic lights.
A signed diversion route will be in place via the A6 and Armathwaite bridge for the duration of the works.
A walkway for pedestrians and dismounted cyclists will be maintained across Eden Bridge as well as access to the recycling area and Swimming Pool from Lazonby.
Cumbria County Council has apologised for any inconvenience that may be caused due to the road closure and says that due to the limited width of the bridge it is not possible to safely install the traffic signals while keeping the road open to vehicles.
The A75 is currently closed between Annan and Dumfries and is expected to remain closed for up to five hours, after a road accident early this morning.
The westbound diversion route is via A75 at Ladyfield, onto the B7020 to Dalton and Lochmaben, onto the A709 and then to the A75 at Dumfries.
The eastbound diversion is the reverse route.
Police are asking motorists to avoid the area if possible.