Snow showers will be heavy and frequent through the rest of Tuesday, gradually easing off during the early hours of Wednesday.
Some high ground is likely to see 15-25 cm building up, especially above 200-300 metres.
At low levels throughout the warning area, 5-10 cm will be more typical.
Showers will be accompanied by hail and lightning at times, while strong winds bring the potential for temporary blizzard conditions and drifting of lying snow, mainly over high ground.
There are no trains running between Carlisle and Glasgow Central/Edinburgh.
It's due to a loss of power to overhead wires between Lockerbie and Carstairs.
Buses have been requested to run between these stations.
Trains may be delayed by up to 90 minutes, cancelled or revised and disruption is expected until 12.00pm.
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Sunny spells and blustery showers on Tuesday.
The showers falling as snow over the hills, and increasingly to lower levels later. Very windy, with coastal gales making it feel cold.
Maximum temperature 5 °C.
Weather warnings tell us to prepare for snow and ice.Read the full story ›
Heavy, squally showers will turn to sleet, hail and snow for many areas of Scotland later on Monday, then parts of Northern Ireland and the far north of England Monday night.
Snow showers will continue through Tuesday and Tuesday night, although perhaps more of sleet and hail near some coasts.
Over the hills, snow will drift in the strong to gale force winds.
This year it will be 100 years since women were given the right to vote.
ITV Border wants to trace descendants of women from our region, who were suffragettes - Miss Slee of Carlisle, Mary Benson of Kendal, Miss Bendelack of Keswick and Miss Laurence of Penrith.
We also want to hear from relatives of any other suffragettes from Cumbria or southern Scotland.
The latest episode of ITV Border's Scottish Political Programme.
Representing Border looks at the issues from Holyrood and Westminster that matter to the South of Scotland.