The Co-operative travel shop in Kelso could close as part a restructuring plan by holiday firm Thomas Cook.
The branch closure in Kelso would see a loss of four jobs.
The Co-operative travel shop on English Street and the Thomas Cook branch on Fisher Street, both in Carlisle, are also on the proposed list of closures, with a potential combined loss of 16 jobs.
Commenting on the proposed closure in the Borders town, the Secretary of State for Scotland, Michael Moore MP, said:
"This is very sad news for the local community in Kelso, particularly for employees at the branch whose jobs are now at risk.
“I know that Co-operative Travel has been experiencing challenging trading conditions in recent years but I am urging them to ensure that the staff affected are given the support they need.
“A 90 day consultation exercise will be held on the plans and I am calling on Co-operative Travel to reconsider this decision and save the branch in Kelso which provides employment and holiday services for local people.”