A road accident on the M6, north of Junction 43 and Junction 44 in Carlisle, is causing major delays on the motorway.
Paramedics are at the scene, although not serious injuries are believed to have occurred.
Lane three has been blocked.
One lane of the M6 motorway in Cumbria is blocked because of a mountain bike in the road, according to the police.
The incident was reported at around 4:30pm, and is affecting the southbound motorway between Junction 36 Kirkby Lonsdale and Junction 35 Carnforth.
Traffic is said to be coping well.
Drivers are being warned of traffic delays on the A66, East from Penrith, due to an abnormal load travelling down that route.
It is expected from 3pm this afternoon.
Abnormal Load travelling A66 East from Penrith after 3pm 12th May...expect delays.
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The A711 in Dumfries and Galloway has been closed due to an accident west of Cargenbridge.
Police Scotland are asking drivers to follow the temporary diversions in place.
Drivers are being warned they face disruption on one of Cumbria's main roads today.
Police say a slow moving abnormal load will be moving west across the A66 towards junction 40 of the M6 at Penrith between 11am and 3pm.
They say motorists travelling along the route at this time should plan extra time for their journeys.
The A686 Hartside Pass road has been blocked by snow, and is impassable between Alston and Melmerby.
The incident was reported just before 9am this morning.
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Police have closed Bridge Street in Carlisle, while they deal with a collision.
Emergency services were called at 2:54pm to a two-vehicle crash, and are still at the scene.
The road leading to Hardwicke Circus has been closed, and drivers are urged to avoid the area.