Scotrail says passengers travelling between Carlisle and Glasgow via Dumfries will face delays from Monday morning.
Two engineering trains collided on Saturday morning damaging the track. No one was hurt.
Trains between Glasgow Central and Carlisle via Dumfries will terminate at Kilmarnock and start back from Dumfries. Replacement buses will run between Kilmarnock and Dumfries.
A crane is being brought in to remove the wagons before the repairs can begin. The line is expected to be closed for about two weeks.
Once the derailed wagons have been recovered the repair work will take approximately three days to complete. Therefore it is expected that the line will remain closed for a number of days. During this time passenger services will start and terminate at Dumfries and Kilmarnock and freight traffic will be diverted via West Coast Main Line and Paisley.
Virgin Trains has cancelled all its West Coast mainline services on Monday and Tuesday ahead of an anticipated strike by Network Rail workers over the Bank Holiday.
Members of the RMT and TSSA unions have voted for a 24-hour strike, starting at 5pm on Monday, amid an ongoing dispute over pay.
In a statement on its website, Virgin Trains said that if the strike goes ahead as planned, then no services will run on either the 25 or 26 of May.
If this industrial action goes ahead, there will be no Virgin Trains services running on the West Coast Mainline on either Monday 25 or Tuesday 26 May.
If the industrial action is called off, some services will be reinstated but we cannot be specific at this stage.
Customers planning to travel on the affected dates will need to make alternative arrangements. If you are planning to travel on Sunday 24 or Wednesday 27 we recommend that you check before you travel for more information on how your journey may be affected.
A spokeswoman for the company told ITV News that East Coast services - which are run by a different operator - would continue on a reduced timetable, and advised customers to check for the latest updates before travelling.
She said bosses were monitoring talks between Network Rail and the unions to see whether the situation may improve.
Anyone with tickets for those dates can use them for either the Sunday or Wednesday, in line with any restrictions on the tickets bought.
The full statement, as well as details about how to get a refund, are available on the Virgin Trains website or by calling 0344 556 5650.
People travelling from Carlisle to Scotland, via Lockerbie, may be delayed by up to 20 minutes.
It's because of a train fault, and disruption is expected to last until 6pm.
Today, the Government announced plans to increase rail services in the North. But what does it mean for Cumbria?Read the full story ›
Cumbria County Council has welcomed today's announcement of what it calls "major changes and investment in the rail network'.
It says the tenders, which will commence in April 2016 and will last for a minimum of seven years, will affect the entire railway network within Cumbria.
Council Leader Cllr Stewart Young said that the changes were the result hard work done through years of lobbying by the council.
The rail services mapped out here will help transform the current second-class rail services Cumbria has been forced to live with through years of underfunding.
"The county council and Cumbria LEP laid out some very clear ‘asks’, and I am delighted that many of these have been answered.
"But there are still improvements we need and we will be working to influence the bidders during the bidding process so that we get the very best rail provision possible."
Windermere and the Furness Line will reportedly benefit from franchise plans announced by the Government this morning.
The new 'Northern Regional' service means that by December 2017, Windermere should have two trains per day to Manchester Airport from Monday to Friday.
It also means that the Furness line is expected to have eight trains a day to Manchester and Manchester Airport, as well as extra trains along the Cumbrian Coast that it's claimed will be timed to better serve workers' shift patterns.
The number of seats on trains in the North West is to increase by a third, under Government plans to reduce overcrowding on the region’s rail network.
There will also be an extra 200 services every day across the Northern and Trans Pennine rail franchises, which cover Cumbria.
Transport Secretary Patrick McLoughlin says that Pacer trains will be scrapped as part of the plans.
The £350 million Borders Railway has been completed with the final section of track laid this morning.
Scottish cabinet secretary for infrastructure, investment and cities Keith Brown arrived at Tweedbank Station by train before clipping the final piece of track into place.
Work to lay the track began in October and the line will open to passengers between Edinburgh and the Borders on September 6 2015.
There is currently disruption to Virgin Trains between Carlisle and Lancaster due to a train that has broken down between Penrith and Oxenholme.
The broken down train may cause delays of up to an hour, and some alterations to travel plans.
The disruption, which is expected to last until at least 1.30pm, is also affecting First Transpennine Express.
People are being asked how much they are likely to use the Borders railway, which opens next year.
The survey is being delivered to homes in Galashiels, Tweedbank, Selkirk and Hawick. It'll also ask what people think about exisiting transport links and how they could be improved.