The A66 is closed both ways closed due to an overturned lorry and recovery work between A685 / B6276 New Road (Brough) and A6 Kemplay Bank / A686 Carleton Avenue (Kemplay Bank Roundabout, Penrith).
Network Rail are urging passengers in the Border region to check before they travel, as Storm Henry approaches Britain.
The wind is expected to strengthen overnight with gusts up to 70mph.
Journeys may be delayed by the 50mph speed limits in place on the Settle - Carlisle railway between Settle and Appleby, the Cumbrian coast line and the West Coast mainline between Garstang and Tebay.
As always, our advice to passengers is to check before you travel, using National Rail Enquiries for the latest information. With even more rain predicted to fall on already saturated ground, there is the potential for localised flooding, as well as possible damage from high winds which may cause disruption to passengers planning to travel."
The railway between Whitehaven and Workington is closed due to the sea wall being breached a Parton.
The sea wall, which supports and protects the railway, and around 700 yards of ballast – the heavy stone which provides the foundations for the railway track – were damaged by high tides as Storm Jonas hit the Cumbrian coastline.
Ian Joslin from Network Rail said:
Our structural experts are on site assessing the damage to the sea wall and track caused by yesterday’s storm but are at the mercy of the tides for some parts of the assessment.
Once the extent of the damage is clear we will be able to plan the repairs so we can safely re-open the line to passengers as quickly as possible.
The A781 is now closed between A780 Buccleuch Street and Dockhead in Dumfries due to flooding.
You can find live updates on road closures here.
Cumbria Police have re-opened the A66 between Brough and Stainmoor, however, high-sided vehicles are being warned to avoid the road.
The A6 is now also closed between Beezon Road Kendal and Blackhall Road Cumbria.
The A6 at Eamont bridge has been closed for some time due to structural damage.
You can find live updates here.
The A66 between A685 Broughand and A6108 Middleton Tyas is closed in both directions due to high winds.
You can find live traffic updates here.
Cumbria's mountain rescue teams helped out around the country when Storm Desmond and Storm Frank hit last December.
But they were also badly affected by the floods, with the estimated cost to the Lake District's mountain rescue teams around £20,000.
Matthew Taylor has this report:
Police are dealing with a road traffic collision on the A66 Appleby road.
They were called at 15.32pm this afternoon with reports of a one vehicle road traffic collision.
Motorists are asked to avoid the area and use alternative routes.