Glasgow and Cumbrian stations will gain more trains as a result of an extension along 171 miles to and from Glasgow.
Trains currently only run over the 230 miles of the route south of Lancaster.
The expansions is part of a new timetable being introduced on the West Coast Main Line.
Carlisle and Penrith North Lakes will be served by additional trains and Oxenholme, The Lake District will gain one more London train in each direction.
The new daily total of 15 Pendolino tilting trains each way represents a doubling of the number of weekday services between Glasgow Central and London Euston since 1997.
A new timetable is being introduced on the West Coast Main Line, providing almost 2,000 extra seats a day on trains for Glasgow.
From Monday 10th December, a train will run every hour with the introduction of two extra Glasgow services running in both directions.
"Overall passenger numbers have more than doubled on our routes. Demand for travel between Glasgow, Cumbria and London has grown steadily since the last big timetable improvement in 2008-9.
"The extra capacity from December will provide a great opportunity for even more passengers to enjoy the service."
The competition to run trains on the West Coast Main Line has been cancelled following the discovery of significant technical flaws in the way the franchise process was conducted, Transport Secretary Patrick McLoughlin has announced.
The decision means the Department for Transport (DfT) will no longer be awarding a franchise contract to run the West Coast service when the current franchise expires in December.
FirstGroup was due to take over the running of the London to Scotland line after being awarded the contract by the DfT in August, but Virgin Rail, which currently runs the service, launched a High Court challenge against the decision
The new contract for the West Coast main line franchise could be signed today. The Government has awarded the contract to FirstGroup after it bid more than £1 billion more than Virgin Trains.
However, the outgoing company is trying to bring about a last minute change of heart, with its boss, Sir Richard Branson, offering to run the service for free while it is scrutinised by Parliament.
Opposition MPs are calling for a debate at Westminster, which returns from its recess next week.
Despite the calls, a spokesman for the Department for Transport indicated that the agreement was set to be signed today saying, "The winning bidder was decided by a fair and established process and no reason has been advanced to convince DfT not to sign the agreement."
Unions, politicians and many rail passengers are calling on the Government to delay the signing of a new franchise for the West Coast main line. Virgin Trains is due to lose the service after FirstGroup made a bid that was more than a billion pounds higher.
Thousands of people have signed a petition opposing the move, but FirstGroup insists its service will provide the best deal for taxpayers and passengers.
RMT leaders have said that First Group have based their bid on the same kind of over-geared financial projections that lead to the collapse of the GNER and National Express contracts on the East Coast – forcing the Government to renationalise the service.
Speaking to ITV Border, RMT Leader, Craig Johnston said he believes the contract will be signed in the coming days without a delay. He said members of the RMT union have expressed concern at the decision.
First Group have responded to calls for a delay to the signing of contracts on the West Coast Main Line rail franchise after more than 100,000 people signed a petition for the decision to be reviewed in Parliament.
First Group Statement:
"We are pleased that the DfT has reiterated that our winning bid was selected by a fair, rigorous process that scrutinised best value and deliverability and that they concluded that no reason has been advanced to convince the DfT not to sign the agreement.
Our bid is deliverable and it provides the best deal for taxpayers, for passengers and for staff on the West Coast Mainline. We will be introducing major service improvements, new trains and cutting standard anytime fares by 15% and by 2016 there will be 40,000 more seats.
We will also provide the taxpayer with a fair and appropriate return for the £9bn of their money that has been spent modernising the line. We are one of the country’s most experienced rail operators and have a good track record.
We won the bid fair and square and we are pleased that the Department for Transport sees no reason to revisit the process."
Statement by Tim O'Toole, Chief Executive of FirstGroup.
Unions, politicians and many rail passengers are calling on the Government to delay the signing of a new franchise for the West Coast Main Line.
Virgin Trains is due to lose the service, which passes through South West Scotland and Cumbria, after First Group made a higher bid.
Labour wants the issue debated in Parliament. 140,000 people have signed a petition opposing the move.
First Group says its bid is deliverable and provides the best deal for taxpayers. It says it was selected in a fair, rigorous process that scrutinised best value and deliverability. It adds that it will be introducing major service improvements, new trains and will cut standard fares.
Shadow Secretary of State for Transport, Maria Eagle MP says the decision should be discussed in Parliament.
Sir Richard has offered to effectively run the route for free to allow the decision awarding the franchise to FirstGroup to be re-examined.Read the full story ›