Glasgow and Cumbrian stations will gain more trains as a result of an extension along 171 miles to and from Glasgow.
Trains currently only run over the 230 miles of the route south of Lancaster.
The expansions is part of a new timetable being introduced on the West Coast Main Line.
Carlisle and Penrith North Lakes will be served by additional trains and Oxenholme, The Lake District will gain one more London train in each direction.
The new daily total of 15 Pendolino tilting trains each way represents a doubling of the number of weekday services between Glasgow Central and London Euston since 1997.