The A66 east of Penrith, near Center Parcs, is currently closed while rescue and recovery work takes place following a crash.
Cumbria Police say diversions are in place. Motorists can use the A65 and A69, the A685 can be used at Brough to join the M6 for westbound traffic but height and weight restrictions apply to the route.
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47-year-old Gary McKee from Cleator Moor ran 100 marathons on 100 successive days, finishing with the London marathon this weekend.
Passengers on services between Carlisle, west Cumbria, Newcastle and on the Carlisle to Settle line can expect delays from Friday.
A village phone box in D&G has been saved from scrap after villagers bought it and converted it into 'The Wee Book Hoose'.