The A66 east of Penrith, near Center Parcs, is currently closed while rescue and recovery work takes place following a crash.
Cumbria Police say diversions are in place. Motorists can use the A65 and A69, the A685 can be used at Brough to join the M6 for westbound traffic but height and weight restrictions apply to the route.
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A 73-mile diversion will be put in place when a three-mile stretch of the A66 between Keswick and Penrith is closed for roadworks.
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