The A75 is currently closed between Annan and Dumfries and is expected to remain closed for up to five hours, after a road accident early this morning.
The westbound diversion route is via A75 at Ladyfield, onto the B7020 to Dalton and Lochmaben, onto the A709 and then to the A75 at Dumfries.
The eastbound diversion is the reverse route.
Police are asking motorists to avoid the area if possible.
More top news
A new multi-million pound school and community hub is officially opening in Harraby today.
Cumbria Fire and Rescue service is warning people to stay safe around lakes and rivers ahead of the Bank Holiday and school half term.
The court heard the mother of four dropped her baby daughter causing a fractured skull, and then assaulted ambulance staff.