The A75 is currently closed between Annan and Dumfries and is expected to remain closed for up to five hours, after a road accident early this morning.
The westbound diversion route is via A75 at Ladyfield, onto the B7020 to Dalton and Lochmaben, onto the A709 and then to the A75 at Dumfries.
The eastbound diversion is the reverse route.
Police are asking motorists to avoid the area if possible.
More top news
10,000 children have increased their chances of avoiding flu this winter after a county council campaign saw figures soar by 40%.
A look ahead over the festive period.
Boxes of Hope, Cumbria, the charity which gets local communities together and helps deprived children in Eastern Europe.