The A75 is currently closed between Annan and Dumfries and is expected to remain closed for up to five hours, after a road accident early this morning.
The westbound diversion route is via A75 at Ladyfield, onto the B7020 to Dalton and Lochmaben, onto the A709 and then to the A75 at Dumfries.
The eastbound diversion is the reverse route.
Police are asking motorists to avoid the area if possible.
More top news
Labour have been pushed into third place in Scotland, but suffers fewer losses than expected in England.
Helen Threlfell died in a collision near Stainton. Her family say she will be greatly missed.
Peter MacMahons' Politics Blog: The SNP have a commanding lead in terms of seats at Holyrood but they do not command the parliament.