A 56-year-old man from Maryport was trapped in his lorry after it left the road and ended up in a field.
The accident happened at the Hardgrove Junction on the A75 between Ruthwell and Dalton, just after 6 o'clock this morning.
The driver was initially trapped, but later managed to climb free and was uninjured.
Dumfries and Galloway Police and the fire service helped clear traffic.
The road is expected to be closed, to allow the lorry to be moved.
More top news
The family of Christian Pay, who died on Friday after suspected substance abuse at a festival, have paid tribute to the Millom teenager.
The Borders Railway is to be officially opened by the Queen... on the day she becomes Britain's longest serving monarch.
Christian Pay's family say he was "loved by all" and had "the heart of a lion". The 18-year-old died after falling ill at the festival.