Friends Colin Stables and Graham Thompson are about to start a gruelling challenge which will see them run for more than six hours a day for nine days.
They're aiming to raise thousands of pounds for the Henderson Suite at the West Cumberland Hospital to support their work with cancer patients.
We've both seen first hand the work the team do at the Henderson Suite. Earlier this year we lost a friend to cancer. If people can find the strength to fight cancer we can find the strength to do this run.'It will be a comforting thought to know that we might make some sort of difference with the money we are raising. It could go towards saving a life, it's just knowing you're making a difference really.'
The duo have spent months training for the run which they start in London tomorrow and finish in Maryport on December 2nd.
The first three days of the challenge have flood warnings in the areas they are running.
'I'm going to pack my flippers and my snorkel. We're just going to put our heads down and help get each other trough. It wouldn't be a challenge if it was easy and hopefully we won't get too waterlogged on the way. Keeping the reason why we are raising the money in our minds will help us get back to Maryport. That's enough motivation.'
The pair will cover a distance of more than 300 miles and have so far raised £1,200, they hope that figure will rise the closer they get to Maryport.
More top news
Cloudy with outbreaks of rain, heaviest in west
Emma Jesson brings you Sunday night's forecast
The Met Office have issued a yellow "Be Aware" warning of heavy rain for the region which is valid from 3pm Sunday until 3pm Monday