Black ice has caused a lorry to come off the road near Moffat.
Police say the vehicle has damaged cables which are now hanging down across the road.
It means the A701 is currently closed to high vehicles.
Traffic police are in attendance at the scene.
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The family of Christian Pay, who died on Friday after suspected substance abuse at a festival, have paid tribute to the Millom teenager.
The Borders Railway is to be officially opened by the Queen... on the day she becomes Britain's longest serving monarch.
Christian Pay's family say he was "loved by all" and had "the heart of a lion". The 18-year-old died after falling ill at the festival.