Black ice has caused a lorry to come off the road near Moffat.
Police say the vehicle has damaged cables which are now hanging down across the road.
It means the A701 is currently closed to high vehicles.
Traffic police are in attendance at the scene.
More top news
Our run of disappointing weather continues - but for how long?
The Margaret Forster Room will be available for hire to the public and will be formally opened by author and broadcaster Hunter Davies.
The Environment Agency are inviting people to share flood protection ideas but many some residents say they just want flood defences built.