Black ice has caused a lorry to come off the road near Moffat.
Police say the vehicle has damaged cables which are now hanging down across the road.
It means the A701 is currently closed to high vehicles.
Traffic police are in attendance at the scene.
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Pictures from the commemoration marking the centenary of the Quintinshill rail disaster, which killed more than 200 people, is underway.
The 100th anniversary of Britain's worst rail disaster will be commemorated at a special service today.