Black ice has caused a lorry to come off the road near Moffat.
Police say the vehicle has damaged cables which are now hanging down across the road.
It means the A701 is currently closed to high vehicles.
Traffic police are in attendance at the scene.
More top news
Emma Jesson brings you Sunday night's forecast
Several Drivers were stranded on the road from County Durham to Cumbria on Saturday when the so-called 'Mini-Beast from the East' arrived.
Emma Jesson brings you Saturday night's forecast