Black ice has caused a lorry to come off the road near Moffat.
Police say the vehicle has damaged cables which are now hanging down across the road.
It means the A701 is currently closed to high vehicles.
Traffic police are in attendance at the scene.
More top news
Your Border forecast for the next few days
50-year-old Tyrone Glaister has been jailed after stabbing a man in a Whitehaven pub with a hunting knife.
A father and son from Jedforest Hunt have denied breaking Scotland's fox hunting laws, after a video showed a fox being chased by hounds.