The northbound stretch of the motorway between J37 and J38 was shut at around 9.40pm to allow vehicles to be recovered and for accident investigators to carry out investigations.
A spokesman for Cumbria Fire and Rescue Service said:
Nobody was trapped in their vehicles, so fire crews assisted the ambulance service with casualty care and first aid."
The road is now re-opened but police are urging motorists to take extra care while a weather warning remains in place until 11am Sunday due to predictions of wintry showers and ice.
More top news
A look ahead at the forecast for the Border region.
Preparations have begun for a two day mountain biking event, the Enduro World Series, in the Tweed Valley this weekend.
Queen of the South have announced the signing on pre-contracts of Robbie Thomson and Ryan Conroy.