Police are warning of surface water on the A74(M) between J15 B7076 / A701 (Moffat) and J17 B7068 (Lockerbie North).
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The train operator says it carried a record breaking 294,000 customers between Glasgow and London on it's west coast route.
47-year-old Gary McKee from Cleator Moor ran 100 marathons on 100 successive days, finishing with the London marathon this weekend.
Passengers on services between Carlisle, west Cumbria, Newcastle and on the Carlisle to Settle line can expect delays from Friday.