The B5305 is blocked in both directions at Sebergham, Cumbria, as a lorry has jacknifed on Sebergham Bridge.
Delays between Wigton and Penrith can be expected and police say the road will not be clear until at least 10am.
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Scottish leader Johann Lamont's resignation highlights the post-referendum divisions.
Remaining windy in the west. Heavy rain on Sunday morning
A consultation is to begin in Melrose to look at the possibility of charging for car-parking all year round in the town's main car park.