Kendal is closed in both directions due to an accident between A6 Highgate / Dowker's Lane and Bankfield Road / Captain French Lane / Brigsteer Road.
Emergency services are at the scene.
There are reports of a possible chemical spill at a nearby building.
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One of the world's most famous locomotives drew huge crowds in Cumbria today, as it arrived after a ten year, £4.2 million, restoration.
One hundred artworks have been donated to an auction, to raise money for victims of flooding in Cumbria.