Kendal is closed in both directions due to an accident between A6 Highgate / Dowker's Lane and Bankfield Road / Captain French Lane / Brigsteer Road.
Emergency services are at the scene.
There are reports of a possible chemical spill at a nearby building.
More top news
A Carlisle charity that takes in unwanted and lost animals has been given almost £15,000 from the Postcode Local Trust.
Kerrie Gosney brings you Sunday night's forecast
Ex-tropical air combined with low pressure will give a more unsettled start to the new working week. Heavy rain possible in the west