The A66 is closed in both directions at Appleby-in-Westmorland, due to an accident involving six vehicles.
Emergency services are at the scene.
The accident is affecting traffic between Penrith and Barnard Castle, with diversions in place via Kirby Stephen.
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29-year-old Matt Campbell collapsed after running 22.5 miles. He received medical treatment at the scene, but died later in hospital.
Kerrie brings you Sunday night's forecast
We're back to average April weather for the week ahead