The A66 is closed in both directions at Appleby-in-Westmorland, due to an accident involving six vehicles.
Emergency services are at the scene.
The accident is affecting traffic between Penrith and Barnard Castle, with diversions in place via Kirby Stephen.
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Kerrie Gosney brings you Sunday night's forecast
Cold with wintry showers, risk of some snow and ice early Monday.
The Met Office have issued a warning for snow showers and icy strectches from Saturday evening until 10 am Monday