The A66 is closed in both directions at Brough in Cumbria, due to a serious accident involving two lorries.
The road is closed at the turn-off for Great Musgrave, affecting traffic between Warcop and Brough.
There is a diversion on place via the A685 and the M6.
Emergency services are at the scene.
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The Met Office have issued a warning for snow showers and icy strectches from Saturday evening until 10 am Monday
Kerrie Gosney brings you Saturday night's forecast
Severe gales possible for a time north of the border overnight. A cold, raw wind sets in Sunday. Showers turning wintry Monday & Tuesday.