The A66 is closed in both directions at Brough in Cumbria, due to a serious accident involving two lorries.
The road is closed at the turn-off for Great Musgrave, affecting traffic between Warcop and Brough.
There is a diversion on place via the A685 and the M6.
Emergency services are at the scene.
More top news
Jane Kirkpatrick, 29, knifed Danielle Nicholson in the legs with a knife she picked up inside her home.
The NSPCC is calling for increased support and training for police to help tackle the issue.
A 73-mile diversion will be put in place when a three-mile stretch of the A66 between Keswick and Penrith is closed for roadworks.