A debate about Britain leaving the European Union could have a negative affect on business in the Borders, according to the Chamber of Commerce.
Members say that simply considering a referendum could have a terrible impact on businesses which export goods to Europe.
Derek Cameron runs a business in the Borders, that exports goods to Europe and the rest of the world.
"I think the Europeans may well, quite rightly get fed up, take the huff and I don't see us being welcomed with open arms if we go into France or Germany."
Scottish Borders Chamber of Commerce Director Andrew Collier said:
"The Borders is very much an area where businesses think globally and yes, they do very well in all parts of the world, but to be out of the EU would be a massive hinderence to them.
"It would be huge, and it is a step that is frankly almost beyond contemplation, and I think businesses in the Borders generally speaking will be very very angry about this, because they see that it is just a huge impediment to trading."