The National Museum of Costume based at Shambellie House, near Dumfries, will not re-open for business in the spring.
The closure of the museum comes as a result of the economic recession and falling visitor numbers.
The museum attracted around 10,000 visitors per year, and 5,000 to the shop, cafe and grounds.
The house was opened as a museum in 1982, and is owned by the Scottish Government.
More top news
In an annual survey taken among local authorities in the UK, 2,463 stray dogs were put to sleep between April 2015 and March 2016.
A month-long arts festival focusing on the achievements and interests of mature people across Cumbria, launches this weekend.
The town's historical market will showcase it's transformation this weekend, as it relaunches it's twice-weekly market with 30 new stalls.