The National Museum of Costume based at Shambellie House, near Dumfries, will not re-open for business in the spring.
The closure of the museum comes as a result of the economic recession and falling visitor numbers.
The museum attracted around 10,000 visitors per year, and 5,000 to the shop, cafe and grounds.
The house was opened as a museum in 1982, and is owned by the Scottish Government.
More top news
Wasdale Mountain Rescue Team was involved in three emergency call outs in the space of 24 hours
There is "room for improvement" in rail safety despite it being 10 years since the last passenger death in a train crash.
The two grenades were on board a fishing boat heading for Stranraer harbour.