The A689 at Wallfoot near Carlisle has re-opened following a crash involving three vehicles, including a mini-bus carrying seven children.
The children aged between 13 and 14, and two adults were taken to the Cumberland Infirmary as a precaution.
The driver of the mini-bus, aged 38 and from Northumberland, was airlifted to hospital.
His injuries are not believed to be serious.
A 51-year-old HGV driver from Essex and a local motorist escaped injury.
Police are appealing for witnesses to the crash, which closed the Carlisle to Brampton road for several hours.