Police want to speak to the driver of a blue BMW, believed to have been involved in a serious accident on the A66 this morning (14th February).
The collision, involving a white Peugeot panel van and a white Vauxhall Vivaro van, happened at 10.30am.
The vans were travelling in opposite directions around two miles east of the Sportsman on the A66.
The 53-year-old driver of the Vivaro van, from Carlisle, was taken to the Cumberland Infirmary, with 'non-life threatening' injuries.
A 23-year-old passenger in the same van was airlifted to James Cook hospital in Middlesbrough with 'very serious' injuries.
The 33-year-old driver of the Peugeot van suffered back and rib injuries.
Anyone who knows the driver of the BMW or who witnessed the accident is asked to contact police on 101.