Police want to speak to the driver of a blue BMW, believed to have been involved in a serious accident on the A66 this morning (14th February).
The collision, involving a white Peugeot panel van and a white Vauxhall Vivaro van, happened at 10.30am.
The vans were travelling in opposite directions around two miles east of the Sportsman on the A66.
The 53-year-old driver of the Vivaro van, from Carlisle, was taken to the Cumberland Infirmary, with 'non-life threatening' injuries.
A 23-year-old passenger in the same van was airlifted to James Cook hospital in Middlesbrough with 'very serious' injuries.
The 33-year-old driver of the Peugeot van suffered back and rib injuries.
Anyone who knows the driver of the BMW or who witnessed the accident is asked to contact police on 101.
– Sergeant Graeme Hodgson, Cumbria Police
"We are currently dealing with a very serious collision which occurred this morning on the A66 around 4-5 miles west of Rheged, near Penrith.
“We have identified several witnesses to the collision who state that a blue BMW which was driving along the road at the time may well have been involved in the collision.
"It may be that the driver is unaware that a collision took place, but it is vital that we trace this vehicle, and the driver, in case they have important information about this morning’s incident."