Around 400 metres of road is covered in glue on the A76, near Sanquhar, after a lorry overturned.
The road is expected to be closed for several hours.
The current diversion is 50 miles long.
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An inquest into the death of two people at north Cumbrian hospital has concluded that systematic failures and negligence were to blame.
Three vehicles were involved in a crash on the A711, leaving two men with injuries that aren't thought to be life-threatening.
Twice as many drivers were found to be drunk behind the wheel this Christmas in Cumbria, compared to the same period last year.