The A76 through Sanquhar is currently closed due a road crash which involved a lorry loaded with glue.
The glue container on the lorry has burst and glue spilling is affecting the road surface.
Diversions are being put in place but drivers are being asked to avoid the area.
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Pictures from the commemoration marking the centenary of the Quintinshill rail disaster, which killed more than 200 people, is underway.
The 100th anniversary of Britain's worst rail disaster will be commemorated at a special service today.