Police say the A76 outside of Sanquhar will remain closed for most of the day, after a glue lorry overturned.
Around 400 metres of the road is currently covered in glue.
The diversion currently in place is:
Southbound onto A70 at Cumnock, onto then B7078 to Abington Services, onto A702, then rejoin the A76.
Police advise northbound motorists to reverse this route.
More top news
A look ahead at the forecast for the Border region.
Pictures from the commemoration marking the centenary of the Quintinshill rail disaster, which killed more than 200 people, is underway.
The 100th anniversary of Britain's worst rail disaster will be commemorated at a special service today.