Police say the A76 outside of Sanquhar will remain closed for most of the day, after a glue lorry overturned.
Around 400 metres of the road is currently covered in glue.
The diversion currently in place is:
Southbound onto A70 at Cumnock, onto then B7078 to Abington Services, onto A702, then rejoin the A76.
Police advise northbound motorists to reverse this route.