Police say the A76 outside of Sanquhar will remain closed for most of the day, after a glue lorry overturned.
Around 400 metres of the road is currently covered in glue.
The diversion currently in place is:
Southbound onto A70 at Cumnock, onto then B7078 to Abington Services, onto A702, then rejoin the A76.
Police advise northbound motorists to reverse this route.
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Emma brings you Saturday's forecast
Longest cold spell of winter so far. Mainly dry and bright, but feeling bitterly cold today. Very wintry further east, blizzards possible
Mountain Rescue has seen a 5% increase in rescues and with the current conditions they're advising people to take extra care.