Police say the A76 outside of Sanquhar will remain closed for most of the day, after a glue lorry overturned.
Around 400 metres of the road is currently covered in glue.
The diversion currently in place is:
Southbound onto A70 at Cumnock, onto then B7078 to Abington Services, onto A702, then rejoin the A76.
Police advise northbound motorists to reverse this route.
More top news
The town's historical market will showcase it's transformation this weekend, as it relaunches it's twice-weekly market with 30 new stalls.
Two women from Dumfries and Galloway have been conned out of £40,000 after scammers posed as BT and gained remote access to their computers.
The proposals have implications for the future of maternity services, community hospitals and emergency care across the county.