The four reactors on the Chapelcross site have all now been defuelled, four months ahead of the original target of June 2013.
An official verification that Chapelcross is fuel free will take place over the next few months.
On completion of the inspection, the world's second oldest commercial nuclear power station will boast 'fuel-free' status for the first time in over 50 years.
"This is a huge achievement for Chapelcross and for the decommissioning and clean-up programme in the UK.
"I have been extremely impressed by the energy and commitment with which Magnox has risen to the challenge and I pay tribute to the workforce at Chapelcross.”
“It gives me great pleasure to offer my congratulations to the Chapelcross team who have now completed the defueling of all four reactors.
“This was an extremely challenging target which required defueling rates to be significantly improved and sustained over a 12 month period.
"The fact that the team was able to achieve that and safely deliver ahead of schedule is a testament to the dedication and professionalism of everyone involved.”
More top news
A look ahead at the forecast for the Border region.
Should a 20mph limit become standard on inner-city roads? Take our poll to give us your thoughts.
Speaking to ITV Border, Lord Sutherland of Houndwood criticised the Higher Education Governance (Scotland Bill).