The A596 in Wigton, Cumbria, is closed in both directions due to an accident involving a lorry and a car between Station Road and Thursby roundabout.
Traffic between Workington and Carlisle is being affected, and a diversion is in place via the A595 Roman Road.
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Pictures from the commemoration marking the centenary of the Quintinshill rail disaster, which killed more than 200 people, is underway.
The 100th anniversary of Britain's worst rail disaster will be commemorated at a special service today.