Two casualties have been airlifted to the Southern General Hospital, with a further casualty taken by ambulance to the Dumfries and Galloway Royal Infirmary.
The Northbound carraigeway is closed and will remain so for a considerable period while investigations are carried out. The Southbound carriageway has one lane now re-opened.
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Emma Jesson brings you Sunday night's forecast
Several Drivers were stranded on the road from County Durham to Cumbria on Saturday when the so-called 'Mini-Beast from the East' arrived.
Emma Jesson brings you Saturday night's forecast