Two casualties have been airlifted to the Southern General Hospital, with a further casualty taken by ambulance to the Dumfries and Galloway Royal Infirmary.
The Northbound carraigeway is closed and will remain so for a considerable period while investigations are carried out. The Southbound carriageway has one lane now re-opened.
More top news
A look ahead at the weekend forecast for the Border region.
After a nine-month re-development, people can now journey on the La'al Ratty railway to the new Ravenglass Railway Museum.
An art exhibition will be taking place this weekend at the Rose Castle, which used to be the private home of the Bishops of Carlisle.