Two casualties have been airlifted to the Southern General Hospital, with a further casualty taken by ambulance to the Dumfries and Galloway Royal Infirmary.
The Northbound carraigeway is closed and will remain so for a considerable period while investigations are carried out. The Southbound carriageway has one lane now re-opened.
More top news
A look ahead at the forecast for the Border region.
Our gallery of wildlife in the Farne Islands, taken by our reporter and a selection of local students.
Mainly dry until later on Wednesday. A cooler, showery and blustery end to May