Two casualties have been airlifted to the Southern General Hospital, with a further casualty taken by ambulance to the Dumfries and Galloway Royal Infirmary.
The Northbound carraigeway is closed and will remain so for a considerable period while investigations are carried out. The Southbound carriageway has one lane now re-opened.
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The town's historical market will showcase it's transformation this weekend, as it relaunches it's twice-weekly market with 30 new stalls.
Two women from Dumfries and Galloway have been conned out of £40,000 after scammers posed as BT and gained remote access to their computers.
The proposals have implications for the future of maternity services, community hospitals and emergency care across the county.