Two riders being transported to hospital. It is not clear at this time the extent of their injuries.
The A686 is currently closed a Melmerby and Alston and motorists are advised to avoid the area and use alternative routes.
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A look ahead at the forecast for the Border region.
The 2017 Wool fest is set to take place over two days in June at Cockermouth's Lakeland Livestock Centre.
Alex Hardie, 53 and Amanda Thompson, 37, were jailed for a total of nearly 11 years after being caught with heroine ingredients in Carlisle.