Two riders being transported to hospital. It is not clear at this time the extent of their injuries.
The A686 is currently closed a Melmerby and Alston and motorists are advised to avoid the area and use alternative routes.
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A look ahead at a lively start to the weekend
The 7th Harley Davidson Wake the Lakes Festival is underway.
Concerns about the safety of the hospital's PFI building have been raised by the NHS Trust. The fire service says improvements are needed.