Two riders being transported to hospital. It is not clear at this time the extent of their injuries.
The A686 is currently closed a Melmerby and Alston and motorists are advised to avoid the area and use alternative routes.
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The first stage of the UK's biggest road cycle race will finish in Kelso, but Cumbria and D&G will miss out on staging the event.
Around 30 firefighters are still at the SIS Pitches warehouse in Maryport, controlling a major fire which started yesterday afternoon.
People interested in fostering young people in the Scottish Borders are being urged to come forward.