Two riders being transported to hospital. It is not clear at this time the extent of their injuries.
The A686 is currently closed a Melmerby and Alston and motorists are advised to avoid the area and use alternative routes.
More top news
Emma Jesson brings you Saturday night's forecast
The Pirelli Rally began with a ceremonial start at the tyre manufacturer's Carlisle factory.
Torrential rain in the run up to today's crucial play off game between Salford City and Workington Reds.