Two riders being transported to hospital. It is not clear at this time the extent of their injuries.
The A686 is currently closed a Melmerby and Alston and motorists are advised to avoid the area and use alternative routes.
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An inspirational Cumbrian girl who won the 2015 WellChild Awards, is calling on others from the region to enter this year's event.
Three men have appeared in court, charged with drugs offences, as part of a probe into the death of a teen who fell ill at Kendal Calling.