Two riders being transported to hospital. It is not clear at this time the extent of their injuries.
The A686 is currently closed a Melmerby and Alston and motorists are advised to avoid the area and use alternative routes.
More top news
Snow and heavy rain may hamper Monday morning rush hour
Often very windy, especially as we head into Sunday, with rain or showers. Met Office 'Be Aware' warnings have been issued
The family of a Cumbrian who suffered a botched blood transfusion are furious there was no reference to compensation in the Spending Review.