Two riders being transported to hospital. It is not clear at this time the extent of their injuries.
The A686 is currently closed a Melmerby and Alston and motorists are advised to avoid the area and use alternative routes.
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Sixty-six-year-old Yvonne Blackman, from Dalton, Lockerbie, was involved in the serious collision on Wednesday 8th of February
Three players from the Border region have been selected to play for Scotland in their Six Nations clash against Wales this Saturday