Two riders being transported to hospital. It is not clear at this time the extent of their injuries.
The A686 is currently closed a Melmerby and Alston and motorists are advised to avoid the area and use alternative routes.
More top news
Emma brings you Saturday's forecast
Longest cold spell of winter so far. Mainly dry and bright, but feeling bitterly cold today. Very wintry further east, blizzards possible
Mountain Rescue has seen a 5% increase in rescues and with the current conditions they're advising people to take extra care.