Two riders being transported to hospital. It is not clear at this time the extent of their injuries.
The A686 is currently closed a Melmerby and Alston and motorists are advised to avoid the area and use alternative routes.
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A look ahead at the forecast for the Border region.
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Michael Wolfe was knocked down by a tractor in Longtown, on 10 August. His family and friends led a funeral procession through the town.