The A590 is closed in both directions following a serious road traffic collision at Lindal in Ulverston.
The accident happened at around 5am and involved a Vauxhall Corsa and an HGV.
The 19-year-old driver of the Vauxhall Corsa, who is a man from Barrow, was airlifted to Royal Preston Hospital after suffering life threatening injuries.
The 39-year-old driver of the HGV, from Waberthwaite, suffered no injuries.
The fire service, air ambulance, and highway agency attended the scene.
The road is closed in both directions and will remain closed for the next three to four hours.
Police are asking motorists to avoid the driver and said light traffic can use the A5087 between Barrow and Ulverston.
HGV's are being asked to park up and wait or use A595 and A5092.