The A684 has been closed between Kendal and Sedburgh Road following a crash involving a sports car and a bus.
Paramedics are at the scene, as well as the Fire Service and the Highways Agency.
The collision happened at junction 37 of the M6 just after midday.
The road remains closed and police are advising that it will be for some time.
They are therefore suggesting that motorists use an alternative route.
More top news
Vigils have been held in the region to mark the 100th anniversary of the battle of the Somme.
Vigils will take place across the region tonight to remember those who fought in the Battle of the Somme 100 years ago.
In our Political Editor's latest blog; the Holyrood recess will be used to look at options for the future with the UK outside the EU.