Two men have been airlifted to hospital following a collision on the A684 between Kendal and Sedburgh Road around 12.30pm today.
A yellow Caterham Seven open top sports car and a blue 52-seater coach from Germany were involved in the crash.
The driver of the sports car, a 41 year old man, and a male passenger were initially trapped in the vehicle and later freed by the fire and rescue services before being airlifted to the Royal Preston Hospital with serious injuries.
The 32 people on the coach, including the driver, were uninjured.
Anyone who may have witnessed the collision or seen the vehicles prior to the incident are being asked to contact Cumbria Police on 101 and ask for PC 1639 Steve Wilson of the Kendal Roads Policing Unit.
The road currently remains closed, but police hope to reopen it within the next two hours.
More top news
A look ahead at the forecast for the Border region.
Parents across Cumbria claim the tests put too much pressure on children at an early age and primary school should be more fun
Campaigners fighting for the release of six British ex-soldiers jailed in India on weapons charges are staging a rally in Carlisle