The A711 in both directions closed due to a fallen tree between the B736 (Palnackie) and the A745 (Dalbeattie).
The road is expected to remain closed for some time.
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Three men from Dumfries and Galloway have won a share of £1million after pitching their road surfacing business idea to Sir Richard Branson.
With 74 empty shops and businesses in the town centre, D&G council says it's going to spend a million pounds to bring visitors back.
Following Friday's vote to leave the European Union, businesses in the region are worried about how their export market will be affected.