Mo Farah and Haile Gebrselassie will battle it out at the front of the race, but every single one of the runners that cross the Tyne Bridge on Sunday will have their own story to tell.
Gemma Carter is one of them and she is following in the footsteps of her father who now has Motor Neurone Disease, the charity Gemma is running for.
Fiona Marley Paterson went to meet them - watch her full report below.
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The Jim Clark Rally is changing the format, this years event on Sunday 31st May will run on private Forestry Commission gravel roads.
Kerrie Gosney brings you Sunday night's forecast
Cold with wintry showers, risk of some snow and ice early Monday.