The A66 has been closed at Threlkeld following a collision involving a car and a cyclist.
Emergency services are currently at the scene at the junction with Threlkeld, near Keswick.
The extent of the cyclist's injuries are not known at this time.
Motorists are being advised to avoid the area and to seek alternative routes.
More top news
Fourteen babies in the Border region were born on Saturday, the same day as her Royal Highness, Princess Charlotte.
Gatehouse of Fleet hosts exhibition of German-born architect who received a medal from Edinburgh College of Art this year.
Kendal town council wants to make Kendal the best destination for arts, culture and festivals in the rural North West.