The A66 has been closed at Threlkeld following a collision involving a car and a cyclist.
Emergency services are currently at the scene at the junction with Threlkeld, near Keswick.
The extent of the cyclist's injuries are not known at this time.
Motorists are being advised to avoid the area and to seek alternative routes.
More top news
Often very windy, especially as we head into Sunday, with rain or showers. Met Office 'Be Aware' warnings have been issued
The family of a Cumbrian who suffered a botched blood transfusion are furious there was no reference to compensation in the Spending Review.
The Scottish Fire and Rescue Service is calling on householders across the south of Scotland to be aware of the danger of candle fires.