The A66 has been closed at Threlkeld following a collision involving a car and a cyclist.
Emergency services are currently at the scene at the junction with Threlkeld, near Keswick.
The extent of the cyclist's injuries are not known at this time.
Motorists are being advised to avoid the area and to seek alternative routes.
More top news
Dialect speakers from around the country have been in the Lake District to celebrate the diversity of the English language.
New figures announced by the Scottish conservatives show an assault on a teacher happens nearly every day in the Scottish Borders.
Kerrie Gosney brings you Sunday night's forecast