The A66 has been closed at Threlkeld following a collision involving a car and a cyclist.
Emergency services are currently at the scene at the junction with Threlkeld, near Keswick.
The extent of the cyclist's injuries are not known at this time.
Motorists are being advised to avoid the area and to seek alternative routes.
More top news
After a day of heavy showers will the sun win out in time for the weekend?
The cyclist was hit by a vehicle which Cumbria Police were trying to trace, after a number of similar incidents in Lancashire.
The Scottish Government faces being fined for not making farm subsidy payments on time after a deadline extension was refused.