The A66 has been closed at Threlkeld following a collision involving a car and a cyclist.
Emergency services are currently at the scene at the junction with Threlkeld, near Keswick.
The extent of the cyclist's injuries are not known at this time.
Motorists are being advised to avoid the area and to seek alternative routes.
More top news
A look ahead at the forecast for the Border region.
Police in the Borders have arrested and charged two men with drugs offences.
A court has heard how a drunk man kept lookout for a Carlisle floods looter - and then stole property himself.