The A66 has been closed at Threlkeld following a collision involving a car and a cyclist.
Emergency services are currently at the scene at the junction with Threlkeld, near Keswick.
The extent of the cyclist's injuries are not known at this time.
Motorists are being advised to avoid the area and to seek alternative routes.
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Cloudy with outbreaks of rain, heaviest in west
Emma Jesson brings you Sunday night's forecast
The Met Office have issued a yellow "Be Aware" warning of heavy rain for the region which is valid from 3pm Sunday until 3pm Monday