The A66 has reopened following an earlier crash involving a cyclist and a Toyota Avensis.
The collision happened shortly before 2 o'clock this afternoon.
The driver of the car, a 43-year-old man from Threlkeld, was not injured.
The cyclist, a 60-year-old man from Florida, received serious injuries and was taken to Newcastle hospital via Air Ambulance.
The road was closed for a time while the emergency services attended the incident.
More top news
We have seen a bit of everything this week when it comes to the weather. Here are some of your pictures
Knife brandished at police during two hour stand off
Revelations that four councillors left a key health meeting before a final vote have sparked widespread anger