The A66 has reopened following an earlier crash involving a cyclist and a Toyota Avensis.
The collision happened shortly before 2 o'clock this afternoon.
The driver of the car, a 43-year-old man from Threlkeld, was not injured.
The cyclist, a 60-year-old man from Florida, received serious injuries and was taken to Newcastle hospital via Air Ambulance.
The road was closed for a time while the emergency services attended the incident.
More top news
Clear spells and frost. Wintry showers in the east at first. Snow and ice may linger until Monday lunchtime in places
Outbreaks of sleet or snow, breezy and turning very cold, the wind chill making temperatures feel like sub-zero. Warnings for snow and ice
Cumbria Police are looking to recruit more than 100 new police constables, just months after the force had been threatened by budget cuts.