The A66 has reopened following an earlier crash involving a cyclist and a Toyota Avensis.
The collision happened shortly before 2 o'clock this afternoon.
The driver of the car, a 43-year-old man from Threlkeld, was not injured.
The cyclist, a 60-year-old man from Florida, received serious injuries and was taken to Newcastle hospital via Air Ambulance.
The road was closed for a time while the emergency services attended the incident.
More top news
Over 500 school pupils and 200 adults took part in a series of local sporting and health events raising £1500 for charities.
UNISON Scotland is urging local government workers around the country to go on strike over pay.
A cycling accident in 2012 left 32-year-old Will Clark paralysed from the neck down, but it didn't take away his love for the outdoors.