The A66 has reopened following an earlier crash involving a cyclist and a Toyota Avensis.
The collision happened shortly before 2 o'clock this afternoon.
The driver of the car, a 43-year-old man from Threlkeld, was not injured.
The cyclist, a 60-year-old man from Florida, received serious injuries and was taken to Newcastle hospital via Air Ambulance.
The road was closed for a time while the emergency services attended the incident.
More top news
A look ahead at the Bank Holiday forecast for the Border region.
Cumbria County Council will start work on a £320,000 resurfacing scheme on 6 June, between 6.00pm and 12.30am.
ITV Border's favourite Tapir has left the Lake District Wildlife Park near Keswick, to travel to his new home in the United Arab Emirates.