The A66 has reopened following an earlier crash involving a cyclist and a Toyota Avensis.
The collision happened shortly before 2 o'clock this afternoon.
The driver of the car, a 43-year-old man from Threlkeld, was not injured.
The cyclist, a 60-year-old man from Florida, received serious injuries and was taken to Newcastle hospital via Air Ambulance.
The road was closed for a time while the emergency services attended the incident.
More top news
The Met Office have issued a yellow "Be Aware" warning of heavy rain for the region which is valid from 3pm Sunday until 3pm Monday
Emma Jesson brings you Saturday night's forecast
Christmas Eve which could be rather frosty, and at present, Christmas Day itself looks like being cold and clear with a few wintry showers