A 60-year-old man from Florida has been taken to hospital in Newcastle with "serious injuries", after his bike collided with a car on the A66.
The accident happened at Threlkeld, near Keswick.
The driver of the car was uninjured in the accident.
Motorists are asked to follow the diversions in place.
More top news
Kerrie brings you Saturday's pollen forecast
Kerrie brings you Saturday's forecast
Showers Saturday afternoon & evening could bring torrential downpours, hail & lightning. Risk of localised flooding and longer journey times